Valproic Acid Producing a Reye-Like Syndrome
نویسندگان
چکیده
منابع مشابه
Valproic acid producing a Reye-like syndrome.
.Although several cases of acute hepatic failure associated with the administration of valproic acid (VPA) have been reported, the pathogenesis of this problem remains unclear. We report the case of a 40 month old male with a chronic seizure disorder treated with VPA and phenytoin for two years, who developed sudden progressive neurological deterioration with evidence of increased intracranial ...
متن کاملReye syndrome and salicylates.
This year in the United States there has been considerable controversy about circumstantial evidence linking salicylates to the pathogenesis of Reye syndrome and, in particular, whether that evidence is sufficiently strong to justify action. After careful review both the Federal government and the American Academy of Pediatrics have warned physicians and parents of the possible risk of Reye syn...
متن کاملReye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.
Three senile patients developed fatal acute encephalopathy while receiving calcium hopantenate. The clinical, biochemical, and pathological picture was similar to Reye's syndrome. Calcium hopantenate is a pantothenic acid antagonist. The serum levels of calcium hopantenate were high in coma, and that of pantothenic acid examined in one patient was lowered. Evidence obtained indicated that the R...
متن کاملVALPROIC ACID- valproic acid solution Par Pharmaceutical ----------
WARNINGS: LIFE THREATENING ADVERSE REACTIONS See full prescribing information for complete boxed warning. Hepato toxicity, including fatalities, usually during first 6 months o f treatment. Children under the age of two years and patients with mitochondrial disorders are at higher risk. Monitor patients c losely, and perform serum liver testing prior to therapy and at frequent intervals thereaf...
متن کاملCT findings in adult Reye syndrome.
Reye syndrome, a condition of unknown etiology, is characterized by encephalopathy and fatty infiltration of the liver after viral infections, notably influenza B and varicella [1] . A history of relatively large doses of aspirin ingested during the infection is usually elicited [2] . Reye syndrome is seen most often in children ages 6 months to 15 years; the computed tomographic (CT) findings ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
سال: 1982
ISSN: 0317-1671,2057-0155
DOI: 10.1017/s0317167100044358